Avaliação do potencial de cicatrização do óleo essencial do fruto de aroeira-vermelha (Schinus terebinthifolius Raddi) em ratas com diabetes mellitus

Abstract

Diabetes Mellitus (DM) is a metabolic disease that arises from the absence of insulin and/or an inability to exhibit in a proper manner their effects. Considering that the difficulty in healing is one of the major diabetes consequences and that the pink pepper has anti-inflammatory and healing potential, we aimed to evaluate the topical use of essential oil of Brazilian red-pepper fruit (Schinus terebinthifolius Raddi) on the healing process of lesions in rats subjected to an experimental model of diabetes type I Aloxanic. After the confirmation of diabetes, the rats were subjected to the removal of subcutaneous tissue in the dorsal region of the animal and divided n groups to the received local treatment (21 days) in control (CT), commercial oil (OC) and Brazilian red-pepper (AV). After surgery, the lesion was macroscopically and microscopically evaluated in the period of 7, 14 and 21 days. The macroscopic analysis revealed a local irritation in PP group, however the microscopic analysis showed an accelerated healing process in this group in comparison with CT and CO animals at the 7th treatment day, with no differences at the 14th and 21st day. Therefore, we can conclude that after 7 days of treatment, the Brazilian red-pepper oil has a beneficial effect on the healing process of diabetic animals.