Efeitos do tratamento com ácido rosmarínico em parâmetros bioquímicos e motores em modelo pré clínico da doença de Parkinson

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. Currently, the main therapeutic approach relieves only motor symptoms, however, it does not prevent or stop the neurodegeneration. Rosmarinic Acid (RA) is an ester of caffeic and 3,4-dihydroxyphenylacetic acids obtained from many plant species such as Salvia officinalis L. (sage) and Rosmarinus officinalis (rosemary). This compound has a wide collection of biological activities, antioxidant and free radical scavenging being key factors in the in vivo outcomes reported for RA, howerer, the literature is scarce in studies showing the effects of RA on healthy animals and MPTP treated animals.