Tratamento crônico com decanoato de nandrolona promove remodelamento cardíaco e alteração da função ventricular esquerda em ratas: papel dos moduladores intracelulares de Ca2+

Abstract

The use of androgenic anabolic steroids (AAS) has grown considerably in the last decades, being used by both men and women, with a significant reduction in the age of these users. The abusive and indiscriminate use of these hormones causes cardiovascular alterations, such as cardiac hypertrophy associated with collagen deposition considered pathological. This cardiac remodeling caused by AAS can trigger hypertension, congestive heart failure, cardiomyopathy, arrhythmias and even sudden death. Usually, AAS are associate with physical exercise, which alone promotes beneficial cardiovascular effects. However, in combination, the beneficial effect of exercise is lost with the occurrence of unfavorable cardiovascular adaptations and ventricular function problems, especially diastolic function, myocardial fibrosis and cardiomyocyte derangement. In addition, little is known about the cardiovascular effects of these drugs on women. This work aims to evaluate the effects of nandrolone decanoate and resistive physical exercise on cardiac contractility in female rats. The animals were separated into 4 groups: C (untrained); EC (submitted to resistive physical exercise in water, 5 times per week); ND (treated with DN, 20 mg/kg/ week for 4 weeks); and NDE (trained and treated). The hemodynamic parameters (+dP/dtmax, -dP/dtmin and Tau) were evaluated in the left ventricle. The heart was collected for histological analysis (H&E) and deposition of collagen (picrusirius red).