Busca de biomarcadores de longevidade humana: investigação do gene IPMK

Abstract

The increase in world life expectancy has brought new challenges to the medicine field. We know that the risk of diseases in old age is associated with specific anthropometric and biochemical parameters. However, it is necessary to improve knowledge about the genetic variants such as the Inositol Polyphosphate Multikinase (IPMK) gene. The IPMK have been involved with processes linked to cell survival, such as energy metabolism, vesicular traffic, oxidative stress and telomeric homeostasis, which can influence the health and survival of the eldery. The main objective of this research was to analyze whether the rs2790234:C>G IPMK polymorphism is associated with longevity in elderly people from Grande Vitória/ES, Brazil. A total of 368 individuals were grouped into 181 controls and 187 long-lived participants, matched by sex and ethnicity. The genotyping methodology was performed through Real-Time Polymerase Chain Reaction using TaqMan SNP Genotyping Assay. Statistical results were obtained using the SPSS sofrware v.29, for Windows. Values p<0.05 were considered statistically significant. The statistical analysis for genotype between the group with individuals carrying at least one G allele (CG or GG) and those carrying the CC genotype was significant (p=0.034). As well, a positive association was found for the G allele and long-lived individuals (OR=10.586; 95% CI:1.270 to 88.256; p=0.029). In the investigation by gender, the G allele was significant for longevity in men. In conclusion, the results suggest a positive association of the rs2790234:G allele from IPMK with long-lived individuals from the population of Vitória/ES, Brazil.