Efeitos do Kefir sobre o tônus autonômico cardíaco e controle barorreflexo da pressão arterial em ratos espontaneamente hipertensos

Abstract

Objective: Studies have shown that the probiotic Kefir has beneficial effects on the treatment of hypertension. The aim of this study was to evaluate the effect of chronic treatment with Kefir on cardiac autonomic tone and arterial baroreflex in spontaneously hypertensive rats (SHR). Methods: Male Wistar and SHR rats at 4 months of age, were separated into 3 groups Wistar, SHR and SHR-Kefir treated for 60 days with Kefir (0,3ml/100g) by gavage. The animals were anesthetized and catheters were implanted in the femoral artery and vein for drugs injection and pulsatile arterial blood pressure (PAP), mean arterial pressure (MAP) and heart rate (HR) records, respectively.