Índice aterogênico do plasma e sua relação com parâmetros antropométricos de pacientes submetidos a cirurgia bariátrica

Abstract

Introduction: The atherogenic index of plasma (AIP) is a marker used to assess the risk for cardiovascular diseases (CVD), and high values may also indicate a risk for obesity. Bariatric surgery (BS) is an alternative for the treatment of severe obesity, and in addition to inducing consistent and lasting weight loss, it can also contribute to a reduction in risk factors for CVD. The relationship between IAP and anthropometric parameters in individuals undergoing CB is still poorly known. The objective of the study was to evaluate the AIP during the follow-up of individuals undergoing BS and its relationship with anthropometric parameters. Methods: The study was carried out with patients from the Bariatric and Metabolic Surgery Program at the Cassiano Antônio Moraes University Hospital, who were evaluated in four moments: before the surgery (T0), in the 2nd (T1) and 6th (T2) months after the surgery. Anthropometric (body mass index, waist circumference, fat and lean mass) and biochemical parameters (lipid profile, glucose and C-reactive protein), and atherogenic index of plasma, calculated by the formula [= log (serum triglycerides concentration/HDL cholesterol)], were evaluated. The data were analyzed by ANOVA of repeated measures or Friedman test according to the data distribution. The level of significance was 5%. Results: Fifty-eight individuals agreed to participate in the study, however, only 26 participants (21 women and 5 men) performed all 4 planned assessments. A significant reduction was observed in all anthropometric parameters and AIP in women and men (p<0.05). A significant correlation was found between the AIP and all anthropometric parameters in both men and women, regardless of the moments (p<0.05). The multiple linear regression age and sex adjusted analysis between the AIP and anthropometric parameters at different times of the study showed a significant association of AIP with all anthropometric parameters (p<0.05) at T2, with the exception of the MM. Conclusion: During the 1-year follow-up period of individuals undergoing CB, there was a reduction in the AIP, suggesting a reduction in cardiovascular risk. In addition to the concomitant reduction in anthropometric and biochemical parameters of the lipid profile, BMI, WC and FM influenced the index in the 6th month after BS.